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Jim Pru

Jim Pru

Jim Pru

Office: VBRB 171
Phone: 509-335-8913

Research Focus:

My research focuses on understanding molecular events coordinating the physiology of embryo implantation using the mouse and domestic ruminants as model organisms. With a basic understanding of these processes, the long-term goal is to identify mechanisms that, when gone awry, contribute to infertility during early gestation (recurrent pregnancy loss). Related to embryo implantation, we are specifically interested in the processes by which the embryo signals its presence as it invades the uterine wall in an effort to establish an exchange apparatus for nutients and waste. As progesterone coordinates many of the aspects of embryo implantation, we are also interested in how ovarian-derived progesterone signals in the endometrium by non-classical mechanisms. We recently demonstrated expression of a novel membrane progestin receptor in the uterus and ongoing studies are designed to test the importance of this putative receptor in uterine function. In related studies, efforts are being made to learn how resident stem/progenitor cells of the endometrium contribute to uterine repair during the estrous/menstrual cycle and following parturition.

Representative Publications:

McCallum ML, Pru CA, Smith AR, Kelp NC, Foretz M, Viollet B, Du M, Pru JK. A functional role for AMPK in female fertility and endometrial regeneration. Reproduction 2018:epub

Peluso JJ, Liu X, Uliasz T, Pru CA, Kelp NC, Pru JK. PGRMC1/2 promote luteal vascularization and maintain the primordial follicles in mice. Reproduction 2018;epub

Banerjee K, Resat H, Pru CA, Pru JK. STAT3 knockdown induces tumor formation by MDA-MB-231 cells. Clin Oncol Res 2018;1:1-8. PMID:30234199

Ciccarelli M, Waqas MS, Pru JK, Tibary A. Oxytocin is not involved in luteolysis and early maternal recognition of pregnancy (MRP) in alpacas. Anim Reprod Sci 2017;187:28-38. PMID:29029875

Clark NC, Pru CA, Pru JK. Novel regulators of hemodynamics in the pregnant uterus, in Molecular Biology of Placental Development and Disease (W.R Huckle, Ed.; 2017, Volume 145 in Progress In Molecular Biology and Translational Science, P. Michael Conn, Series Editor) in press

Kelleher AM, Peng W, Pru JK, Pru CA, DeMayo FJ, Spencer TE. Forkhead box a2 (FOXA2) is essential for uterine function and fertility. Proc Natl Acad Sci 2017;epub PMID:28049832

Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional ablation of progesterone receptor membrane component 2 causes female premature reproductive senescence. Endocrinology 2016;epub PMID:28005395

McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional ablation of progesterone receptor membrane component 1 results in subfertility in the female and development of endometrial cysts. Endocrinology 2016;157:3309-3319. PMID: 27309940

Clark NC, Friel AM, Pru CA, Zhang L, Shioda T, Rueda BR, Peluso JJ, Pru JK. Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and growth of xenograft tumors. Cancer Biol Ther 2016;17:262-271. PMID:26785864

Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X, Spencer KR, Logan DW, Matsunami H, Peluso JJ, Stowers L. Cyclic regulation of sensory perception by a female hormone alters behavior. Cell 2015;161:1334-1344. PMID: 26046438

Friel AM, Zhang L, Pru CA, Clark NC, McCallum ML, Blok LJ, Shioda T, Peluso JJ, Rueda BR, Pru JK. Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors. Cancer Lett 2015;356:434-442. PMID:25304370

Griffin D, Liu X, Pru CA, Pru JK, Peluso JJ. Expression of progesterone receptor membrane component-2 within the immature rat ovary and its role in regulating mitosis and apoptosis of spontaneously immortalized granulosa cells. Biol Reprod 2014;91:36. PMID: 24990806

Pru JK, Clark NC. PGRMC1 and PGRMC2 in uterine physiology and disease. Front Neurosci. 2013; 7:168. PMID: 24065879

Patterson AL, Pru JK. Long-term label retaining cells localize to distinct regions within the female reproductive epithelium. Cell Cycle. 2013; 12:2888-2898. PMID: 24018418

Patterson AL, Zhang L. Arango NA, Teixeira J, Pru JK. Mesenchymal-to-epithelial transition contributes to endometrial regeneration following natural and artificial decidualization. Stem Cell Dev. 2013; 22:962-974. PMID: 23216285