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Zhihua Jiang Research

Zhihua Jiang – Research


Comparative Genome Biology

Since the early 1990’s, my research has focused on Comparative Genome Biology. The long-term goal of this research program is to understand how genomes have evolved and shuffled in vertebrate animals. The well-annotated human genome serves as a reference for us to understand genome structures and functions of other animals; such as bear, cattle, dog, frog, sheep, swine and water buffalo. The “link” markers to correlate various genomes include orthologous genes, ultraconserved elements, and single nucleotide polymorphisms. Two approaches – TOAST and CAGE were developed to generate the “link” markers for orthologous genes and ultraconserved elements. The TOAST (Traced Orthologous Amplified Sequence Tags) approach experimentally transfers homologous sequence information from the well-studied species to the less-studied species. The CAGE (Comparative Annotation of Genes and Elements) approach uses the well-annotated gene/element information in one species to electronically retrieve its ortholog in another species when it has a large amount of DNA/RNA sequences available in the public databases. The transfers of single nucleotide polymorphisms among species rely on the microarray technology. Genome mapping of these markers were based on three approaches: digital chromosomal painting, RH (radiation hybrid), and HAPPY (the HAPloid DNA samples using the PolYmerase chain reaction) mapping. Combination of the HAPPY mapping with next generation sequencing is the newest technique we are pursuing to further advance our comparative genome biology research.

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Complex Phenotype Mapping

Understanding the molecular basis of complex phenotypes/quantitative genetic variations is a principal goal for biomedicine in human, and genetic improvement in agriculture species. However, identification of genes responsible for the variations in complex phenotypes has been a challenge in modern genetics. During the last several years, my lab has accumulated three critical research resources for mapping of quantitative trait loci (QTL) for economically important traits in livestock species. The resources include a dairy population of ~1,600 bulls from 15 sire families (donated by Dr. Ashwell), a beef population of ~360 animals from a Wagyu x Limousin cross(donated by Dr. MacNeil), and a pig population of ~800 animal challenged by the PRRS virus (donated by Dr. Lunney). Recently we pursued both single marker-single trait association and multiple markers-single trait regression analyses, and revealed genetic networks associated with economically important traits in beef cattle. Such genetic networks involving both genotypes and quantitative trait modes (QTMs) resulted in high correlations between predicted and actual values of performance; thus providing evidence that the classical Mendelian principals of inheritance can be applied in understanding the genetic complexity of complex phenotypes. Development of genomically standardized farming systems and a forward QTL mapping approach are examples of our current interests in the area.

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Animal Healthome Network

In 2012, animal health was determined as one of the five grand challenges by the American Society of Animal Sciences. Direct losses through diseases in livestock may result from increased mortality of breeding or production animals, decreased efficiency of production process and reduced quantity, quality and unit value of product, while indirect losses due to disease may include veterinary care, detriment of human well-being and extra management efforts. For example, PRRSV causes severe reproductive failure of the sow, including third-trimester abortions, early farrowing with stillborns, mummies, neonatal death and weak piglets, agalactia and mastitis, and prolonged anoestrus and delayed return to heat post-weaning. Respiratory disease is the major clinical sign in neonatal pigs and is characterized by fever, interstitial pneumonia, eyelid edema, periocular edema, blue discoloration of the ears and shaking. The mortality in neonatal pigs infected with PRRSV can reach 100%. In growing/finishing pigs, subclinical infection is much more common. Some PRRSV-infected boars demonstrate a loss of libido, lethargy, lowered sperm volume and low fertility. A recent study estimated that PRRS costs the pork industry $664 million per year in the United States of America. Our long-term goal of the Animal Healthome Network is to provide a foundation for the community to determine interactions between host and pathogen, and discover essential pathways of host resistance to diseases.

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Peer-reviewed Professional Articles (*Senior Authorship)

 

137. Jiang Z*, Zhou X, Michal JJ, Wu XL, Zhang L, Zhang M, Ding B, Liu B, Manoranjan VS, Neill JD, Harhay GP, Kehrli ME Jr, Miller LC. 2013.  Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. PLoS One. 8(3):e59229.

136.  Zhang L, Mousel MR, Wu X, Michal JJ, Zhou X, Ding B, Dodson MV, El-Halawany NK, Lewis GS, Jiang Z*. 2013. Genome-wide genetic diversity and differentially selected regions among Suffolk, Rambouillet, Columbia, Polypay, and Targhee sheep. PLoS One. 8(6):e65942.

135.  Zhou X, Michal JJ, Zhang LF, Ding B, Lunney JK, Liu B, Jiang Z*. 2013. Interferon-induced IFIT family in host antiviral defense.  International Journal of Biological Sciences 9(2): 200-208.

134.  Zhou X, Jiang T, Du X, Zhou P, Jiang Z, Michal JJ, Liu B. 2013.  Molecular characterization of porcine SARM1 and its role in regulating TLRs signaling during highly pathogenic porcine reproductive and respiratory syndrome virus infection in vivo.  Developmental & Comparative Immunology 39:117-26.

133.  Wang H, Xiong K, Sun W, Fu Y, Jiang Z, Yu D, Liu H, Chen J. 2013. Two completely linked polymorphisms in the PPARG transcriptional regulatory region significantly affect gene expression and intramuscular fat deposition in the longissimus dorsi muscle of Erhualian pigs. Anim Genet. 44:458-62.

132.  Liu J, Bai J, Lu Q, Zhang L, Jiang Z, Michal JJ, He Q, Jiang P. 2013.  Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach  revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine circovirus type 2. J Proteomics. 79:72-86.

131.  Liu J, Bai J, Zhang L, Jiang Z, Wang X, Li Y, Jiang P. 2013.  Hsp70 positively regulates porcine circovirus type 2 replication in vitro. Virology. 447(1-2):52-62.

130.  Wei S, Zhang L, Zhou X, Du M, Jiang Z, Hausman GJ, Bergen WG, Zan L, Dodson MV. Emerging roles of zinc finger proteins in regulating adipogenesis. Cell Mol
Life Sci. 70:4569-84.

129.  Wei S, Du M, Jiang Z, Duarte MS, Fernyhough-Culver M, Albrecht E, Will K, Zan L, Hausman GJ, Elabd EM, Bergen WG, Basu U, Dodson MV. 2013.  Bovine dedifferentiated adipose tissue (DFAT) cells: DFAT cell isolation. Adipocyte. 2:148-59.

128.  Wei S, Zan LS, Wang HB, Cheng G, Du M, Jiang Z, Hausman GJ, McFarland DC, Dodson MV. 2013.  Adenovirus-mediated interference of FABP4 regulates mRNA expression of ADIPOQ, LEP and LEPR in bovine adipocytes. Genet Mol Res. 12:494-505.

127. Liu J, Bai J, Lu Q, Zhang L, Jiang Z, Michal JJ, He Q, Jiang P. 2012. Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine circovirus type 2.  Journal of Proteomics 79C:72-86.

126.  Li RS, Sun QW, Jia YM, Cong RH, Ni YD, Yang XJ, Jiang Z, Zhao RQ. 2012. Coordinated miRNA/mRNA expression profiles for understanding breed-specific metabolic characters of liver between Erhualian and Large White Pigs.  PLoS ONE 7: e38716.

125. Lu Q, Bai J, Zhang LL, Liu J, Jiang Z, Michal JJ, Jiang P. 2012.  Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric Tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus.  Journal of Proteome Research 11: 2890–2903.

124. Zhang LF, Michal JJ, O’Fallon JV, Pan ZX, Gaskins CT, Reeves JJ, Busboom JR, Zhou X, Ding B, Dodson MV, Jiang Z*. 2012. Quantitative genomics of 30 complex phenotypes in Wagyu x Angus F1 progeny. International Journal of Biological Sciences 8: 838-858.

123.  Wei S, Duarte MS, Du M, Paulino PVR, Jiang Z, Albrecht E, Fernyhough-Culver M, Zan L, Dodson MV. 2012. Bovine mature adipocytes readily return to a proliferative state. Tissue & Cell 44:385-390.

122.  Duarte MS, Wei S, Du M, Jiang Z, Paulino PVR, Zan L, Hausman GJ, Dodson MV. 2012. Isolation of mature adipocytes and stromal vascular cells under adverse sampling conditions. Journal of Metabolic Syndrome 1(4):112-116.

121.  Wei S, Duarte MS, Du M, Jiang Z, Paulino PVR, Chen J, Fernyhough-Culver ME, Hausman GJ, Zan L, Dodson MV. 2012. Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro. Adipocyte 1:237-241.

120.  Kunej T, Jevsinek Skok D, Zorc M, Ogrinc A, Michal JJ, Kovac M, Jiang Z*. 2012. Obesity gene atlas in mammals. Journal of Genomics 1: 45-55.

119. Dodson MV, Wei S, Duarte MS, Du M, Jiang Z, Hausman GJ, Bergen WG. 2012. Cell supermarket: Adipose tissue as a source of stem cells. Journal of Genomics 1: 39-44.

118.  Wei S, Duarte MS, Zan LS, Du M, Jiang Z, Guan LL, Chen J, Hausman GJ, Dodson MV. 2012.  Cellular and Molecular Implications of Mature Adipocyte Dedifferentiation. Journal of Genomics 1: 5-12.

117.  Godnic I, Calin GA, Horvat S, Jiang Z, Jevsinek Skok D, Zorc M, Dovc P, Kunej T. 2012.  Catalog of microRNA seed polymorphisms in vertebrates.  PLoS ONE 7: e30737.

116.  Dodson MV, Jiang Z, Du M, Hausman GJ. 2012. Adipogenesis: It is not just lipid that comprises adipose tissue.  Journal of Genomics 1:1-4.

115.  Dodson MV, Mir P, Hausman GJ, Guan LL, Du M, Jiang Z, Fernyhough ME, Bergen WG. 2011. Obesity, metabolic syndromes and adipocytes.  Journal of Lipid 721686.

114.  Jiang Z*, Michal JJ, Beckman KB, Lyons JB, Zhang M, Pan ZX, Rokhsar DS, Harland RM.  Development and initial characterization of a HAPPY panel for mapping the X. tropicalis genome.  International Journal of Biological Sciences 7: 1037 – 1044.

113.  Jiang Z*, Michal JJ, Wu X-L, Pan ZX, MacNeil MD. 2011. The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition.  International Journal of Biological Sciences 7: 659 – 663.

112.  Dodson MV, Hausman GJ, Guan LL, Du M, Jiang Z. 2011. Potential impact of mature adipocyte dedifferentiation in terms of cell numbers. International Journal of Stem Cells 4:76-78.

111.  Michelizzi VN, Wu X-L, Dodson MV, Michal JJ, Zambrano-Varon J, McLean DJ, Jiang Z*. 2011. A global view of 54,001 single nucleotide polymorphisms (SNPs) on the Illumina BovineSNP50 BeadChip and their transferability to water buffalo. International Journal of Biological Sciences 7: 18-27.

110.  Kunej T, Skok DJ, Horvat S, Dovc P, Jiang Z*.  2010. The glypican 3-hosted murine Mir717 gene: sequence conservation, seed region polymorphisms and putative targets.  International Journal of Biological Sciences 6: 769-772.

109.  Dodson MV, Hausman GJ, Guan LL, Du M, Rasmussen TP, Poulos SP, Mir P, Bergen WG, Fernyhough ME, McFarland DC, Rhoads RP, Soret B, Reecy JM, Velleman SG, Jiang Z. 2010.  Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research.  International Journal of Biological Sciences 6:691-699.

108.  Dodson MV, Hausman GJ, Guan LL, Du M, Rasmussen TP, Poulos SP, Mir P, Bergen WG, Fernyhough ME, McFarland DC, Rhoads RP, Soret B, Reecy JM, Velleman SG, Jiang Z. 2010. Skeletal muscle stem cells from animals I. Basic cell biology. International Journal of Biological Sciences 6: 465-474.

107.  Michelizzi VN, Dodson MV, Pan ZX, Amaral ME, Michal JJ, McLean DJ, Womack JE, Jiang Z*. 2010. Water buffalo genome science comes of age.  International Journal of Biological Sciences 6: 333-349.

106.  Daniels TF, Wu X-L, Pan ZX, Michal JJ, Wright Jr. RW, Killinger KM, MacNeil MD, Jiang Z*. 2010. The reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth.  PLoS ONE 5(12): e15203.

105.  Dodson MV, Vierck JL, Hausman GJ, Guan LL, Fernyhough ME, Poulos SP, Mir P, Jiang Z. 2010. Examination of adipose depot-specific PPAR moieties. Biochemical and Biophysical Research Communications 394:241-242.

104.  Chen J, Dodson MV, Jiang Z*. 2010. Cellular and molecular comparison of redifferentiation of intramuscular- and subcutaneous- adipocyte derived progeny cells. International Journal of Biological Sciences 6:80-88.

103.  Dodson MV, Guan LL, Fernyhough ME, Mir PS, Bucci L, McFarland DC, Novakofski J, Reecy JM, Ajuwon KS, Thompson DP, Hausman GJ, Benson ME, Bergen WG, Jiang Z. 2010. Perspectives on the formation of an interdisciplinary research team. Biochemical and Biophysical Research Communications 391:155-1157.

102.  Dodson MV, Jiang Z, Chen J, Hausman GJ, Guan LL, Novakofski J, Thompson DP, Lorenzen CL, Fernyhough ME, Mir P, Reecy JM.  2010.  Allied industry approaches to alter intramuscular fat content and composition in beef animals.  Journal of Food Science 75:R1-8.

101.  Kunej T, Wu X-L, Michal JJ, Milosevic-Berlic T, Jiang Z*, Dovc P.  2009.  The porcine mitochondrial transcription factor A gene: molecular characterization, radiation hybrid mapping and genetic diversity among 12 pig breeds.  American Journal of Animal and Veterinary Sciences 4: 129-135.

100.  Jiang Z*, Michal JJ, Chen J, Daniels TF, Kunej T, Garcia MD, Gaskins CT, Busboom JR, Alexander LJ, Wright Jr. RW, MacNeil MD.  2009.  Discovery of novel genetic networks associated with 19 economically important traits in beef cattle.  International Journal of Biological Sciences 5:528-542.

99. Daniels TF, Killinger KM, Michal JJ, Wright Jr. RW, Jiang Z*. 2009. Lipoproteins, cholesterol homeostasis and cardiac health.  International Journal of Biological Sciences 5:474-488.

98. Chen J, Guridi M, Fernyhough ME, Jiang Z*, Guan LL, Hausman GJ, Dodson MV. 2009. Initial differences in lipid processing leading to pig- and beef-derived mature adipocyte dedifferentiation.  Basic and Applied Myology 19:243-246.

97.  Chen J, Guridi M, Fernyhough ME, Jiang Z*, Guan LL, Hausman GJ, Dodson MV. 2009. Clonal mature adipocyte production of proliferative-competent daughter cells requires lipid export prior to cell division. International Journal of Stem Cells 2:76-79.

96. Xu XL, Xu XW, Pan PW, Li K, Jiang Z, Yu M, Rothschild MF, Liu B.  2009.  Porcine skeletal muscle differentially expressed gene CMYA1: isolation, characterization, mapping, expression and association analysis with carcass traits.  Animal Genetics 40: 255 – 261.

95.  Jiang Z*, Rokhsar DS, Harland RM. 2009.  Old can be new again: HAPPY whole genome sequencing, mapping and assembly.  International Journal of Biological Sciences 5:298-303.

94. Wang XX, Xue CY, Wang XN, Liu HL, Xu YX, Zhao RQ, Jiang Z, Dodson MV, Chen J. 2009. Differential display of expressed genes reveals a novel function of SFRS18 in regulation of intramuscular fat deposition.  International Journal of Biological Sciences 5: 28 – 33.

93.  Hausman GJ, Dodson MV, Ajuwon K, Azain M, Barnes KM, Guan LL, Jiang Z*, Poulos SP, Sainz RD, Smith S, Spurlock M, Novakofski J, Fernyhough ME, Mersmann H. 2009.  Board Sponsored Invited Review: Domestic animal carcass composition: The biology and regulation of preadipocytes and adipocytes.  Journal of Animal Science 87:1218-1246.

92.  Wibowo TA, Gaskins CT, Newberry RC, Thorgaard GH, Michal JJ, Jiang Z*. 2008.  Genome assembly anchored QTL map of bovine chromosome 14.  International Journal of Biological Sciences 4:406 – 414.

91.  Wang XX, Chen J, Liu HL, Xu YX, Wang XN, Xue CY, Yu DB, Jiang Z.  2008. The pig p160 co-activator family: full length cDNA cloning, expression and effects on intramuscular fat content in Longissimus Dorsi muscle.  Domestic Animal Endocrinology 35: 208 – 216.

90. Jiang Z*, Michal JJ, Tobey DJ, Daniels TF, Rule DC, MacNeil MD.  2008. Significant associations of stearoyl-CoA desaturase (SCD1) gene with fat deposition and composition in skeletal muscle.  International Journal of Biological Sciences 4:345 – 351.

89.  Jiang Z*, Wu X-L, Zhang M, Michal JJ, Wright Jr. RW.  2008.  The complementary neighborhood patterns and methylation-to-mutation likelihood structures of 15,110 single nucleotide polymorphisms in the bovine genome.  Genetics 180:639-647.

88. Jiang Z*, Michal JJ, Tobey DJ, Wang ZP, MacNeil MD, Magnuson NS. 2008. Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus.  International Journal of Biological Sciences 4:96-102.

87.  Chen J, Yang XJ, Xia D, Chen J, Wegner J, Jiang Z, Zhao RQ. 2008. Sterol regulatory element binding transcription factor 1 expression and genetic polymorphism significantly affect intramuscular fat deposition in the longissimus muscle of Erhualian and Sutai pigs.  Journal of Animal Science 86:57-63.

86.  Jiang Z*, Wang ZP, Kunej T, Williams GA, Michal JJ, Wu X-L, Magnuson NS.  2007. A novel type of sequence variation – multiple nucleotide length polymorphisms discovered in the bovine genome.  Genetics 76:403-407.

85. Jiang Z*, Rothschild MF.  2007.  Swine genome science comes of age (Editorial).  International Journal of Biological Sciences 3:129-131.

84.  Rothschild MF, Hu Z-L, Jiang Z. 2007.  Advances in QTL mapping in pigs.  International Journal of Biological Sciences 3:192-197.

83. Williams GA, Ott TL, Michal JJ, Gaskins CT, Wright Jr. RW, Daniels TF, Jiang Z*. 2007. Development of a novel model for mapping cryptorchidism in sheep and initial evidence for association of INSL3 with the defect.  Animal Genetics 38: 189-191.

82. Xiao QJ, Wibowo TA, Wu X-L, Michal JJ, Reeves JJ, Busboom JR, Thorgaard GH, Jiang Z*. 2007.  A simplified QTL mapping approach for screening and mapping of novel AFLP markers associated with beef marbling.  Journal of Biotechnology 127:177-187.

81.  Jiang Z*, Pappu SS, Rothschild MF. 2007.  Hitting the jackpot twice: identifying and patenting gene tests related to muscle lipid accumulation for meat quality in animals and type 2 diabetes/obesity in humans.  Recent Patents on DNA & Gene Sequences 1:100-111.

80. Kunej T, Wang Z, Michal JJ, Daniels TF, Magnuson NS, Jiang Z*.  2007.  Functional UQCRC1 polymorphisms affect promoter activity and body lipid accumulation. Obesity 15:2896-901.

79.  Wibowo TA, Michal JJ, Jiang Z*. 2007. The corticotropin releasing hormone is a promising candidate gene for marbling and subcutaneous fat depth in beef cattle.  Genome 50:939-945.

78. Jiang Z*, Michal JJ, Williams GA, Daniels TF, Kunej T. 2006. Cross species association examination of UCN3 and CRHR2 as potential pharmacological targets for antiobesity drugs.  PloS ONE 1(1):e80.

77. Xiao Q, Wu X-L, Michal JJ, Reeves JJ, Busboom JR, Thorgaard GH, Jiang Z*.  2006. A novel nuclear-encoded mitochondrial poly(A) polymerase PAPD1 is a potential candidate gene for the extreme obesity related phenotypes in mammals.  International Journal of Biological Sciences 2:171-178.

76. Michal JJ, Zhang ZW, Gaskins CT, Jiang Z*.  2006. The bovine fatty acid binding protein 4 gene is significantly associated with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses.  Animal Genetics 37:400-402.

75. Sharma BS, Jansen GB, Karrow NA, Kelton D, Jiang Z*. 2006. Detection and characterization of AFLP markers for clinical mastitis in Canadian Holsteins.  Journal of Dairy Science 89:3653-3663.

74. Garcia MD, Michal JJ, Gaskins CT, Reeves JJ, Ott TL, Liu Y, Jiang Z*.  2006.  Significant associations of the calpastatin gene with fertility and longevity in dairy cattle.  Animal Genetics 37:304-305.

73. Schenkel FS, Miller SP, Jiang Z*, Mandell IB, Ye X, Li H, Wilton JW. 2006. Association of a single nucleotide polymorphism in the calpastatin (CAST) gene with carcass and meat quality traits of beef cattle. Journal of Animal Science 84:291-299.

72. Kunej T, Michal JJ, Dovc P, Jiang Z*. 2005. Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu x Limousin F2 crosses. Acta Agriculturae Slovenica 86: 99-102.

71. Griffin KB, Michal JJ, Fox LK, Gaskins CT, Jiang Z*. 2005. Fine mapping of the bovine chromosome 22q24 region that harbors antimicrobial genes and a QTL for somatic cell score.  Animal Genetics 36: 448-450.

70. Wu X-L, MacNeil MD, De S, Xiao QJ, Michal JJ, Gaskins CT, Reeves JJ, Busboom JR, Wright Jr, RW, Jiang Z*.  2005. Evaluation of candidate gene effects for beef backfat via Bayesian model selection.  Genetica 125:103-113.

69. Jiang Z*, Michal JJ, Melville JS, Baltzer HL. 2005. Multi-alignment of orthologous genome regions in five species provides new insights into the evolutionary makeup of mammalian genomes. Chromosome Research 13:707-715.

68. Jiang Z*, Wu X-L, Michal JJ, McNamara JP. 2005. Pattern profiling and mapping of the fat body transcriptome in Drosophila melanogaster. Obesity Research 13:1898-1904.

67. Jiang Z*, Kunej T, Michal JJ, Gaskins CT, Reeves JJ, Busboom JR, Dovc P, Wright Jr. RW. 2005.  Significant associations of the mitochondrial transcription factor A (TFAM) promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses.  Biochemical and Biophysical Research Communications 334:516-523.

66.  Pan ZX, Liu HL, Chen J, Xu D, Jiang Z, Xie Z. 2005. In silico discovery of genes expressed in liver, kidney, spleen and small intestine of pigs.  Asian-Aust. J. Anim. Sci. 18: 170-178.

65. Jiang Z*, De S, Garcia MD, Griffin KB, Wu X-L, Xiao QJ, Michal JJ, Sharma BS, Jansen GB. 2005. An independent confirmation of a quantitative trait locus for milk yield and composition traits on bovine chromosome 26.  J. Anim. Breed. Genet. 122:281-284.

64. Kunej T, Wu X-L, Milosevic Berlic T, Michal JJ, Jiang Z*, Dovc P. 2005. Frequency distribution of a Cys430Ser polymorphism in peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) gene sequence in Chinese and Western pig breeds.  J. Anim. Breed. Genet. 122: 7 – 11.

63. Jiang Z*, Wu X-L, Garcia MD, Griffin KB, Michal JJ, Ott TL, Gaskins CT, Wright Jr. RW. 2004. Comparative gene-based in silico transcriptome analysis of different tissues/organs in cattle. Genome 47:1164-1172.

62. Cao H, Robinson JA, Jiang Z*, Melville JS, Golovan SP, Jones MW and Verrinder Gibbins AM. 2004.  A high-resolution radiation hybrid map of porcine chromosome 6.  Animal Genetics 35:367-378.

61. Wu X-L, Griffin KB, Garcia MD, Michal JJ, Xiao Q-J, Wright Jr. RW, Jiang Z*. 2004. Census of orthologous genes and self-organizing maps (SOM) of biologically relevant transcriptional patterns in chickens (Gallus gallus). Gene 240:213-225.

60. Jiang Z*, Michal JJ.  2003.  Linking porcine microsatellite markers to known genome regions by identifying their human orthologs. Genome 46:798-808.

59. Jiang Z*, Zhang M, Wasem VD, Michal JJ, Zhang H, Wright Jr. RW. 2003. Census of genes expressed in porcine embryos and reproductive tissues by mining EST database based on the human genes.  Biology of Reproduction 69:1177-1182.

58. Craig JA, Sharma BS, Jiang Z*. 2003. The sequence of the bovine cysteine- and histidine-rich cytoplasmic gene: EST puzzle solving by comparative assembly and confirmation by genomic sequencing. J. Anim. Breed. Genet. 120:210-215.

57. King AM, Jiang Z*, Gibson JP, Haley CS, Archibald AL. 2003. Mapping quantitative trait loci affecting female reproductive traits on porcine chromosome 8.  Biology of Reproduction 68:2172-2179.

56. Gibson JP, Jiang Z*, Robinson JA, Archibald AL, Haley CS. 2002.  No detectable association of the ESR PvuII mutation with sow productivity in a Meishan x Large White F2 population.  Animal Genetics 33:448-450.

55. Jiang Z*, Rottmann OJ, Krebs O, Chen J, Liu H, Pirchner F. 2002. A missence mutation in the follicle stimulating hormone receptor (FSHR) gene shows different allele effects on litter size in Chinese Erhualian and German Landrace pigs. J. Anim. Breed. Genet. 119:335-341.

54. Jiang Z*, Melville JS, Cao H, Kumar S, Filipski A, Gibbins AM. 2002. Measuring conservation of contiguous sets of autosomal markers on bovine and porcine genomes in relation to the map of the human genome. Genome 45:769-776.

53. Jiang Z*, He H, Hamasima N, Suzuki H, Verrinder G. 2002. Comparative mapping of Homo sapiens chromosome 4 (HSA4) and Sus scrofa chromosome 8 (SSC8) using orthologous genes representing different cytogenetic bands as landmarks.  Genome 45:147-156.

52. Jiang Z*, Renier C, Andre C, Galibert F. 2001. RH mapping of canine TOAST markers: a new strategy for species specific primer design to prevent amplification of host orthologous gene products especially with similar sizes. Mammalian Genome 12:799-801.

51. Ledwidge SA, Mallard BA, Gibson JP, Jansen GB, Jiang Z. 2001. Multi-primer target PCR for rapid identification of bovine DRB3 alleles. Animal Genetics 32:219-221.

50. Jiang Z*, Gibson JP, Archibald AL, Haley CS. 2001. The porcine gonadotropin-releasing hormone receptor (GnRHR) gene: genomic organization, genetic polymorphisms and association with prolificacy. Genome 44:7-12.

49. Lahbib-Mansais Y, Leroux S, Milan D, Yerle M, Robic A, Jiang Z, Andre C, Gellin J. 2000.  Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) using porcine somatic cell and radiated hybrid panels. Mammalian Genome 11:1098-1106.

48. Jiang P, Chen PY, Dong YY, Cai JL, Cai BX, Jiang Z. 2000. Isolation and genome characterization of porcine reproductive and respiratory syndrome virus in P.R. China. Journal of Veterinary Diagnostic Investigation 12:156-158.

47. Priat, C., Jiang Z*, Renier C, Andre C, Galibert F. 1999.  Characterization of 463 type I markers suitable for dog genome mapping. Mammalian Genome 10:803-813.

46. Jiang Z*, Rottmann OJ, Pirchner F. 1999.  Rapid communication: A BstXI polymorphism in the porcine matrix metalloproteinase 1 (MMP1) gene locus. J. Anim. Sci. 77:1026-1027.

45. Vignaux F, Priat C, Jouquand S, Hitte C, Jiang Z, Cheron A, Renier C, Andre C, Galibert F. 1999.  Toward a dog radiation hybrid map.  Journal of Heredity 90:62-67.

44. Jiang Z*, Gibson JP. 1999.  Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds. Mammalian Genome 10:191-193.

43. Jiang Z*, Gibson JP. 1999.  Bi-PASA genotyping of a new polymorphism in the APOB gene shows no evidence for an association with fatness in pigs.  Animal Genetics 30:54-56.

42. Priat C, Hitte C, Vignaux F, Renier C, Jiang Z*, Jouquand S, Chéron A, André C, Galibert F. 1998. A whole-genome radiation hybrid map of the dog genome. Genomics 54:361-378.

41. Jiang Z*, Priat C, Galibert F. 1998.  Traced orthologous amplified-sequence tags (TOASTs) and mammalian comparative maps. Mammalian Genome 9:577-587.

40. Galibert F, André C, Chéron A, Chuat JC, Hitte C, Jiang Z, Jouquand S, Priat C, Renier C, Vignaux F. 1998. The advantages of the canine model in human genetics. Bulletin de l’academie de Medecine 182:811-822.

39. Jiang Z*, Gibson JP. 1998. Rapid communication: A PCR– RFLP marker at the porcine complement factor B (BF) gene locus shows between population frequency variation.  J. Anim. Sci. 76:1716-1717.

38. Jiang Z*, Gibson JP. 1998. Rapid communication: A PCR amplified product length polymorphism (APLP) marker at the porcine glucosephosphate isomerase (GPI) locus shows between population frequency variation. J. Anim. Sci. 76:1718-1719.

37. Jiang Z*, Jouquand S. Galibert F. 1997.  Identification and characterization of a SSCP marker at the canine signal sequence receptor beta subunit gene. Animal Genetics 28:460-461.

36. Jiang Z*, Rottmann OJ, Pirchner F. 1996. Hha I enzyme reveals genetic polymorphisms at the second exon of porcine-growth -hormone gene. J. Anim. Breed. Genet. 113:553-558.

35. Archibald AL, Couperwhite S, Jiang Z. 1996. The porcine TTR locus maps to chromosome 6q. Animal Genetics 27:351-353.

34. Jiang Z*, Ge YS, Zhang J. 1988. Crossbreeding of pigs – its development and experimental results in China.  Pig News and Information 9:257-263.

33. Jiang Z*, Wang LY. 1985. Genetic resources and pig production in PR China. Stocarstvo 39:361-365.

Professional Articles in Chinese, Refereed

32. Pan ZX, Chen J, Huang RH, Xu D, Xu YX, Xie Z, Jiang Z, Liu HL, Zhao RQ. 2005. Analysis of gene expression information in the fat and muscle tissues of pig.  Yi Chuan Xue Bao. 32:264-74.

31. Chen J, Liu HL, Jiang Z*, Wu YN. 2002. Association of FSHR gene with litter size in pigs using PCR-SSCP analysis.  Journal of Nanjing Agricultural University. 25(3):53-56.

30. Wu YN, Liu HL, Chen J, Xu YX, Jiang Z*. 2000.  Application of Bi-PASA technique in genotyping RYR1 polymorphism.  Journal of Nanjing Agricultural University. 23(2):69-71.

29. Guo XL, Jiang Z*, Liu HL. 1999. RFLPs analysis of the steroid 21-hydroxylase gene in Erhualian and Large White pigs.  Journal of Animal Science and Veterinary Medicine. 30 (1):1-5.

28. Chen J, Jiang Z*, Liu HL, Li QX, Fan MY, Wu YN. 1999. Relationship between PCR-SSCP at FSHB locus and litter size in Erhualian pigs.  Journal of Nanjing Agricultural University 22 (2): 55-58.

27. Fan MY, Liu HL, Jiang Z*, Li QX, Chen J, Wu YN. 1999.  Detecting the polymorphisms of insulin like growth factor 1 gene locus in six pig breeds.  Animal Husbandry and Veterinary Medicine 31(1):12-13.

26. Niu SL, Zheng XB, Gu YY, Feng ZY, Gan XD, Jiang Z. 1999. Relationships between glucose content and AKP activitiy in the flushing from oviduct and ovulation rate and number of foetus in Erhualian and Large white pigs. Animal Husbandry and Veterinary Medicine 31(3):5-6.

25. Zhu WR, Jiang Z*, Liu HL, Huang YY. 1998.  PCR-SSCP analysis of porcine PGD, MOS and HXB gene loci.  Shanghai Animal Science and Veterinary Medicine (1):12-13.

24. Liu HL, Jiang Z*, Fan MY, Zhu WR, Chen J. 1998.  Hha I polymorphisms of growth hormone gene in main indigenous pig breeds of China.  Journal of Jiangsu Agriculture 14:85-89.

23. Jiang Z*, Liu HL, Li QX, Hu XY. 1997. Studies on maternal and genetic effects on early growth traits in Erhualian and Large White pigs. Journal of Nanjing Agricultural University 20 (3):69-72.

22. Li XB, Jiang Z*, Liu HL. 1997.  RAPD analysis and animal breeding.  YuenNan Animal Science and Veterinary Medicine (2):34-36.

21. Jiang Z*, Rottmann OJ, Pirchner F. 1997. Sequence characterization of genetic polymorphisms at the 2nd exon of porcine growth hormone gene.  Journal of Nanjing Agricultural University 20 (2):67-71.

20. Fan MY, Jiang Z*, Liu HL, Huang YY. 1997.  Porcine PSS genotyping using PCR-SSCP and PCR-RFLP methods.  Swine  (1):28-29.

19. Ding B, Jiang Z*, Liu HL, Huang YY. 1997.  DNA fingerprinting analysis of two pig families.  Journal of Animal Science and Veterinary Medicine 28:1-5.

18. Guo XL, Jiang Z*, Liu HL, Huang YY. 1997. Studies on RFLPs of the steroid 21-hydroxylase locus in pigs. Journal of Nanjing Agricultural University 20 (1):48-54.

17. Ding B, Jiang Z*, Liu HL, Huang YY, Zhu WR. 1996. DNA fingerprints of Large White and Erhualian pigs generated with Human minisatellite probes. Journal of Nanjing Agricultural University 19(1):60-63.

16. Zhu WR, Jiang Z*, Liu HL, Huang YY. 1996.  Halothan gene detection in Jinhua, Wanzehua and Landrace pigs.  Journal of Agricultural Biotechnology 4:299-300.

15. Jiang Z*, Niu SL, Feng ZY, Gan XD, Liu HL. 1995. Studies on gene effects of main component traits of litter size in Erhualian and Large White pigs. Journal of Nanjing Agricultural University 18 (2):79-83.

14. Xu YX, Xia ZZ, Gan J, Jiang Z. 1995. Chromosome C-banding polymorphisms in different crossbreds of pigs.  Journal of Jiangsu Agriculture 11(1): 28-32.

13. Gao F, Jiang Z*, Chen ML. 1995. The genetic polymorphisms of amylase in pigs. Animal Science and Veterinary Medicine  (3) 108-110.

12. Xu YX, Xia ZZ, Gan J, Jiang Z. 1994. Comparison of C-banding polymorphisms in Erhualian and Large White pigs.  Journal of Nanjing Agricultural University 17(2): 70-74.

11. Ding B, Jiang Z*, Guo XL, Liu HL Huang YY. 1994. DNA fingerprints of Erhualian and Large White pigs generated with six restriction endonucleases.  Journal of Nanjing Agricultural University 17(3):75-80.

10. Xu YX, Xia ZZ, Gan J. Jiang Z. 1994.  Chromosome C-banding polymorphisms as genetic markers in pigs. Journal of Jiangsu Agriculture 10(3):46-50.

9. Guo XL, Jiang Z*, Li QX, Tao CZ. 1992. Preliminary study on inheritance of high prolificacy in Taihu pigs. Shanghai Bulletin on Animal Science and Veterinary Medicine (1):2-3.

8. Chen WG, Jiang Z*, Li QX, Hu XY. 1991. Study on maternal heterosis of reproduction performance in Erhualian and its crossbreds.  Shanghai Bulletin on Animal Science and Veterinary Medicine (5):7-8.

7. Yu S, Jiang Z*, Li QX, Zhou DS. 1991. Inheritance of number of teats and their association with reproduction performance in sows.  Shanghai Bulletin on Animal Science and Veterinary Medicine (2):13-14.

6. Jiang Z*, Yu BP, Liu HL, Ge QS. 1990.  Crossbreeding of pigs in China.  Swine (4):18-23.

5. Ge QS, Yu BP, Jiang Z*, Wang GQ. 1989. Effects of magnetized water on growth and development of quail.  Shanghai Bulletin on Animal Science and Veterinary Medicine (4):11-13.

4. Yu BP, Ge QS, Jiang Z*. 1989. Effects of magnetized water on egg production in quail. Shanghai Bulletin on Animal Science and Veterinary Medicine (1):11-13.

3. Jiang Z*, Sviben M. 1988.  The first parity performance of gilts as selection bases (I).  Jiangsu Agricultural Sciences (1):33-34.

2. Jiang Z*, Sviben M. 1988.  The first parity performance of gilts as selection bases (II).  Jiangsu Agricultural Sciences (2):33-34.

1. Jiang Z*, Sviben M. 1987.  Long-term selection and trends of population parameters.  Journal of Nanjing Agricultural University 10(4):91-96.