Holly Neibergs

Holly Neibergs
ASLB 210

ANIMAL GENOMICS. Recent advances in animal genetics have accelerated with the use of genomics. This laboratory focuses on the use of mammalian comparative and functional genomics in the search for genes of economic significance. This includes identification of genes involved in disease resistance as well as production traits with the use of linkage, epidemiological and functional approaches. By utilizing different approaches to unravel the genetic basis of complex traits, these studies offer new tools for genetic selection and improvement of animals. Current projects include identification of loci associated with susceptibility to bovine respiratory disease and bovine paratuberculosis in beef and dairy cattle, identification of loci associated with feed efficiency in beef cattle and identification of loci associated with fertility in beef and dairy.

Specific Research Areas

  • Genetic components of animal health.
  • Complex traits of economic significance.
  • Genomics of fertility


  1. T.P.L. Smith, D.M. Bickhart, D. Boichard, A.J. Chamberlain, A Djikeng, Y. Jiang, W.Y. Low, H. Pausch, S. Demyda-Peyras, J. Prendergast, R.D. Schnabel, B.D. Rosen, Bovine Pangenome Consortium. 2023. The bovine pangenome consortium: democratizing production and accessibility of genome assemblies for global cattle breeds and other bovine species. Genome Biology 24, 1390. https://doi.org/10.1186/s13059-023-02975-0
  2. M. Court, J.N. Kiser, H.L. Neibergs, Zhaohui Zhu, J Dillberger. 2023. Identification of genes associated with delayed postoperative hemorrhage in Scottish deerhounds by whole genome sequencing. J Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16643
  3. R.D. Oliveira, M.R. Mousel, M.V. Gonzalez, C.J. Durfee, K.M. Davenport, B.M. Murdoch, J.B. Taylor, H.L. Neibergs, S.N. White. 2022. A high density genome-wide association with absolute blood monocyte count in domestic sheep identifies novel loci. PLOS ONE https://doi.org/10.1371/journal.pone.0266748
  4. J.N. Kiser, H.L. Neibergs. 2021. Identifying loci associated with bovine corona virus in dairy and beef cattle. Frontiers in Veterinary Science – Veterinary Infectious Diseases. https://doi.org/10.3389/fvets.2021.679074
  5. A.T. Massa, M.R. Mousel, C. Durfee, M.K. Herndon, K.M. Hemmerling J.B. Taylor, H.L. Neibergs, S.N. White. 2021. A DNA regulatory element haplotype at Zinc Finger genes is associated with host resilience to ovine lentivirus in multiple populations. Animals. 11(7). 1907 https://doi.org/10.3390/ani11071907 
  6. J.E. Williams, M.K. McGuire, C.L. Meehan, M.A. McGuire, S.L. Brooker, E.W. Kamau-Mbuthia, E.W. Kaumundi, S. Mbugua, S.E. Moore, A.M. Prentice, G.E. Otoo, J.M. Rodriguez, R.G. Pareja, J.A. Foster, D.W. Sellen, D.G. Kiat, H.L. Neibergs, B.M. Murdoch. 2021. Key Genetic Variants Associated with Variation of Milk Oligosaccharides from Diverse Human Populations. Genomics. 113(4):1867-1875 https://doi.org/10.1016/j.ygeno.2021.04.004   
  7. J.N. Kiser, Z. Wang, R. Zanella, E. Scraggs, M. Neupane, B. Cantrell, C.P. Van Tassell, S.N. White, J.F. Taylor, H.L. Neibergs. 2021. Functional variants surrounding EDN2 are associated with Mycobacterium avium subspecies paratuberculosis infection. Frontiers in Veterinary Science; Advances in the Diagnosis and Control of Johne’s Disease. https://doi.org/10.3389/fvets.2021.625323
  8. M.U. Çinar, B. Akyüz; K. Arslan; S.N. White; H.L. Neibergs; K.S. Gümüşsoy. 2020. The EDN2 rs110287192 gene polymorphism is associated with paratuberculosis susceptibility in multibreed cattle population. PLOS ONE https://doi.org/10.1371/journal.pone.0238631
  9. R.H. Nissly, N. Zaman, P.A.S. Ibrahim, K. McDaniel, L. Lim, J.N. Kiser, I. Bird, S.K. Chothe, G.L. Bhushan, K. Vandegrift, H.L. Neibergs, S.V. Kuchipudi. 2020. Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD. Virology 551(December) 10 https://doi.org/10.1016/j.virol.2020.08.014
  10. J.M. Galliou, J.N. Kiser, K.F. Oliver, C.M. Seabury, J.G.N. Moraes, J. Dalton, G.W. Burns, T.E. Spencer, H.L. Neibergs. 2020. Identification of loci and pathways associated with heifer conception rate in U.S. Holsteins. Genes 11(7) 767. https://doi.org/10.3390/genes11070767
  11. H.L. Neibergs. 2020. Genomics: Host Genotype and Relevance to BRD. Animal Health Research Reviews. https://doi.org/10.1017/S1466252320000134
  12. K.F. Oliver, T.W. Geary, J.N. Kiser, J.M. Galliou, M.L. Van Emon, C.M. Seabury, T.E. Spencer, H.L. Neibergs. 2020. Brief Report: Loci associated with conception rate in crossbred beef heifers. PLOS One. https://doi.org/10.1371/journal.pone.0230422