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Holly Neibergs

Holly Neibergs

Holly Neibergs

Professor
Office: ASLB 210
Phone: 509-335-6491
neibergs@wsu.edu

ANIMAL GENOMICS. Recent advances in animal genetics have accelerated with the use of genomics. This laboratory focuses on the use of mammalian comparative and functional genomics in the search for genes of economic significance. This includes identification of genes involved in disease resistance as well as production traits with the use of linkage, epidemiological and functional approaches. By utilizing different approaches to unravel the genetic basis of complex traits, these studies offer new tools for genetic selection and improvement of animals. Current projects include identification of loci associated with susceptibility to bovine respiratory disease and bovine paratuberculosis in beef and dairy cattle, identification of loci associated with feed efficiency in beef cattle and identification of loci associated with fertility in beef and dairy.

Specific Research Areas:

  • Genetic components of animal health.
  • Complex traits of economic significance.
  • Genomics of fertility

Publications:

  1. J.N. Kiser, E.M. Keuter, C.M. Seabury, M. Neupane, J.G.N. Moraes, J. Dalton, G.W. Burns, T.E. Spencer, H.L. Neibergs. 2019. Validation of 46 loci associated with fertility traits in cattle. BMC Genomics https://doi.org/10.1186/s12864-019-5935-3
  2. J.L. Hoff, J.E. Decker, R.D. Schnabel, C.M. Seabury, H.L. Neibergs, J.F. Taylor. 2019. QTL-mapping and genomic prediction for bovine respiratory disease in U.S. Holsteins using sequence imputation and feature selection. BMC Genomics 20:555 https://doi.org/10.1186/s12864-019-5941-5
  3. C. Rexroad, J. Vallet, L.K. Matukumalli, J. Reecy, D. Bickhart, H. Blackburn, M. Boggess, H. Cheng, A. Clutter, N. Cockett, C. Ernst, J.E. Fulton, J. Liu, J. Lunney, H. Neibergs, C. Purcell, T.P.L. Smith, T. Sonstegard, J. Taylor, B. Telugu, A. Van Eenennaam, C. P. Van Tassell, K. Wells. 2019. Genome to Phenome: Improving animal health, production and well-being a new USDA blueprint for animal genome research 2018-2027. Frontiers in Genetics https://doi.org/10.3389/fgene.2019.00327
  4. E. Clancy, J.N. Kiser, M. Neupane, J.G.N. Moraes, J. Dalton, T.E. Spencer, H.L. Neibergs. 2019. Genome wide association and gene set enrichment analysis-SNP identify genes associated with 305-day milk yield in Holstein dairy cows. Animal Genetics. https://dx.doi.org/10.1111/age.12792
  5. J.N. Kiser, M.A. Cornmesser, K. Gavin, A.  Hoffman, D.A. Moore, H.L. Neibergs. 2018. Rapid communication: Genome-wide association analyses identify loci associated with colostrum production in Jersey cattle. Journal Animal Science https://doi.org/10.1093/jas/sky482
  6. M. Neupane, J.N. Kiser, the Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, H.L. Neibergs. 2018. Gene set enrichment analysis of SNP data (GSEA-SNP) in dairy and beef cattle with bovine respiratory disease. Animal Genetics doi: 10.1111/age.12718
  7. K. Gavin, H.L. Neibergs, A. Hoffman, J.N. Kiser, M.A. Cornmesser, J.R. Wenz, D.A. Moore. 2018. Low colostrum yield in Jersey cattle and potential risk factors. J Dairy Science. doi: 10.3168/jds.2017-14308
  8. J.G.N. Moraes, S.K. Behura, T.W. Geary, P.J. Hansen, T.R. Hansen, H.L. Neibergs, T.E. Spencer. 2018. Uterine influences on conceptus development in fertility-classified heifers. Proceedings National Academy of Science USA. 10.1073/pnas.1721191115
  9. S.K. Behura, P.C. Tizioto, J. Woo Kim, N.V. Grupioni, C.M. Seabury, R.D. Schnabel, L.J. Gershwin, A.L. Van Eenennaam, R. Toaff-Rosenstein, H.L. Neibergs, L.C. Regitano, the Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, J.F. Taylor. 2017. Tissue tropism in host transcriptional response to members of the bovine respiratory disease complex. Scientific Reports. 7:17938 doi:10.1038/s41598-017-18205-0
  10. M. Neupane, T.W. Geary, J.N. Kiser, G.W. Burns, T.E. Spencer, H.L. Neibergs. Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle. PLoSOne. 12(12): e0188997.doi: 10.1271/journal.pone.0188997
  11. J.N. Kiser, M. Neupane, S.N. White, H.L. Neibergs. Identification of genes associated with susceptibility to Mycobacterium avium ssp. paratuberculosis (Map) tissue infection in Holstein cattle using gene set enrichment analysis – SNP. Mammalian Genome. https://doi.org/10.1007/s00335-017-9725-4
  12. C.M. Seabury, D.L. Oldeschulte M. Saatchi, J.E. Beever, J.E. Decker, Y.A. Halley, E.K. Bhattarai, M. Molaei, H.C. Freetly, S.L. Hansen, H. Yampara-Iquise, K.A. Johnson, M.S. Kerley, J. Woo Kim, D.D. Loy, E. Marques, H.L. Neibergs, R.D. Schnabel, D.W. Shike, M.L. Spangler, R.L. Weaber, D.J. Garrick, J.F. Taylor. 2017. Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle. BMC Genomics. 18:386. DOI: 10.1186/s12864-017-3754-y
  13. J.N. Kiser, T.E. Lawrence, M. Neupane, C.M. Seabury, J.F. Taylor, J. E. Womack, the Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, H.L. Neibergs. 2017. Rapid Communications: Subclinical bovine respiratory disease – loci and pathogens associated with lung lesions in feedlot cattle. Journal Animal Science. 95(3):1080-1091. DOI:10.2527/jas.2016.1152
  14. M. Neupane, K.D. Moss, F. Avila, T. Raudsepp, B.M. Marron, J.E. Beever, S. Parish, J.N. Kiser, B. Cantrell, H.L. Neibergs. Case study: Polymelia in a Holstein calf. Professional Animal Scientist. 33(3):378-386. DOI:10.15232/pas.2016-01594 (1, 2, 6)
  15. N. Kiser, S.N. White, K.A. Johnson, J.L. Hoff, J.F. Taylor, H.L. Neibergs. 2017. Identification of loci associated with susceptibility to Mycobacterium avium subspecies paratuberculosis (Map) tissue infection in cattle. Journal of Animal Science. 95(3):1080-1091. DOI:10.2527/jas.2016.1152
  16. C.J. Cassady, T.L. Felix, J.E. Beever, D.W. Shike, National Program for Genetic Improvement of Feed Efficiency in Beef Cattle. 2016. Effects of timing and duration of test period and diet type on intake and feed efficiency of Charolais-sired cattle. Journal of Animal Science. 94(11):4748-4758. DOI:10.2527/jas.2016-0633
  17. J. Russell, N. Minton, W. Sexton, M. Kerley, S. Hansen. 2016. National Program for Genetic Improvement of Feed Efficiency in Beef Cattle. Journal of Animal Science. 94(4):1610-1619. DOI: 10.2527/jas.2015-9949
  18. T.W. Geary, G.W. Burns, J.G.N. Moraes, J.I. Moss, A.C. Denicol, K.B. Dobbs, S. Ortega, P.J. Hansen, M.E. Wehrman, H. Neibergs, E. O’Neil, S. Behura, T.E. Spencer. 2016. Identification of beef heifers with superior uterine capacity for pregnancy. Biology of Reproduction 95(2):47. DOI:10.1095/biolreprod.116.141390
  19. J. Dalton, D. Moore, T.E. Spencer, P.J. Hansen, J.B. Cole, and H. Neibergs. 2016. Genetics, genomics, and fertility. Clinical Theriogenology. 8(3):165-170.
  20. L.J. Gershwin, A.L. Van Eenennaam, M.L. Anderson, H. McEligot, M. Shao, S. Yarnes, R. Toeff-Rosenstein, J.F. Taylor, H.L. Neibergs, and Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team. 2015. Single pathogen challenge with agents of the bovine respiratory disease complex. PLosOne. 10(11):e0142479. DOI:10.1371/journal.pone.0142479
  21. P.C. Tizioto, J.W. Kim, C.M. Seabury, R.D. Schnabel, L.J. Gershwin, A.L. Van Eenennaam, R. Toaff-Rosenstein, H.L. Neibergs, the Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, J.F. Taylor. 2015. Immunological response to single pathogen challenge with agents of the bovine respiratory disease complex: An RNA-sequence analysis of the bronchial lymph node transcriptome. PlosOne. 10(6):e0131459. DOI:10.1371/journal.pone.0131459
  22. T.F. Ng, N. Kondov, X. Deng, A. Van Eenennaam, H.L. Neibergs, E. Delwart. 2015. A metagenomics and case-control study to identify viruses associated with bovine respiratory disease. Journal Virology. 89(10):5340-5349.  DOI:10.1128/JVI.00064-15
  23. H.L. Neibergs, C.M. Seabury, A.J. Wojtowicz, Z. Wang, E. Scraggs, J. Kiser, M. Neupane, J.E. Womack, A. E. Van Eenennaam, G.R. Hagevoort, T.W. Lehenbauer, S. Aly, J. Davis, J.F. Taylor. 2014. Susceptibility loci revealed for bovine respiratory disease complex in pre-weaned Holstein calves. BMC Genomics. 15:1164.
  24. A. Van Eenennaam, H.L. Neibergs, C. Seabury, J. Taylor, Z. Wang, E. Scraggs,  R.D. Schnabel, J. Decker, A. Wojtowicz, S. Aly, J. Davis, P. Blanchard, B. Crossley, P. Rossitto, T. Lehenbauer, R. Hagevoort, E. Chavez, J.S. Neibergs, J.E. Womack. 2014.  Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility. Animal Health Research Reviews. 15(2):157-160. DOI:http://dx.doi.org/10.1017/S1466252314000231
  25. M. Saatchi, J.E. Beever, J.E. Decker, H.C. Freetly, S.L. Hansen, H. Yampara-Iquise, K.A. Johnson, M.S. Kerley, J.W. Kim, D.D. Loy, E. Marques, H.L. Neibergs, E.J. Pollak, R.D. Schnabel, C.M. Seabury, D.W. Shike, M.L. Spangler, R.L. Weaber, D.J. Garrick, J.F. Taylor. 2014. QTL, candidate genes, metabolic and signaling pathways associated with growth, metabolic mid-test weight, feed intake and fee efficiency in beef cattle. BMC Genomics. 15:1004. DOI:10.1186/1471-2164-15-1004