Professor of Comparative Genomics
Office: VBRB 151
COMPARATIVE RNA BIOLOGY Transcriptome analysis is fundamental to understanding the biochemical, cellular, physiological and environmental systems involved in the complex phenotypes that affect development, growth, reproduction and well-being in human and animals. In mammals, up to 75% of genes use alternative promoters, isoforms or polyadenylation sites, contributing greatly to transcriptome flexibility, diversity and dynamics. The long-term goal of our Comparative RNA Biology program is to create state-of-the-art tools for profiling the full transcriptome that will advance the field of functional genomics and increase its applicability to solve unmet problems in human health and animal productivity. We believe that accurate profiling of transcript variants will promote the discovery of genetic mutations that underlie complex phenotypes, aid in the selection of regulatory switch units for functional characterization, and discover alternative variants that can be used for disease diagnosis and drug discovery in humans and for biomarker selection in animals.
Specific Research Areas:
- Development of next-generation sequencing tools for profiling of alternative transcripts.
- Development of alternative transcript resources in animals and model organisms.
- Development of animal models to understand alternative transcripts and multi-functions of genes.
Most Recent Publications:
For a complete list of publications, please visit https://www.researchgate.net/profile/Zhihua_Jiang4/
- Wang WM, Zhang XX, Zhou X, Zhang YZ, La YF, Zhang Y, Li C, Zhao YZ, Li FD, Liu B, Jiang Z. 2019. Deep genome resequencing reveals artificial and natural selection for visual deterioration, plateau adaptability and high prolificacy in Chinese domestic sheep. Front. Genet. doi: 10.3389/fgene.2019.00300.
- Jiang Z. 2019. RNA and the key to the diversity of life. Scientia (https://doi.org/10.26320/SCIENTIA312).
- Zhou X, Zhang Y, Michal JJ, Qu LJ, Zhang SW, Wildung MR, Du W, Pouchnik DJ, Zhao Hui, Xia Y, Shi HH, Ji GL, Davis JF, Smith GD, Griswold MD, Harland RM, Jiang Z. 2019. Alternative polyadenylation coordinates embryonic development, sexual dimorphisms and longitudinal growth in Xenopus Tropicalis. Cell Mol Life Sci. (https://doi.org/10.1007/s00018-019-03036-1).
- Zhang YQ, Carrion SA, Zhang YZ, Zhang XH, Zinski AL, Michal JJ, Jiang Z. Alternative polyadenylation analysis in animals and plants: newly developed strategies for profiling, processing and validation. Int J Biol Sci. 2018;14:1709-1714.
- El-Halawany N, Kandil OM, Shawky AA, Al-Tohamy AF, El-Sayd YA, Abdel-Shafy H, Abou-Fandoud EI, Abdel-Azeem SN, Abd El-Rahim AH, Abdoon AS, Michal JJ, Jiang Z. Investigating the effect of GDF9, BMP15, BMP6 and BMPR1B polymorphisms on Egyptian sheep fecundity and their transcripts expression in ovarian cells. Small Ruminant Res. 2018;165:34-40.
- Zhang SW, Zhang YZ, Zhou X, Fu X, Michal JJ, Ji GL, Du M, Davis JF, Jiang Z. Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice. Sci Rep. 2018;8:6462.
- Zhu JM, Huang X, Hu LL, Michal JJ, Jiang Z, Shi HH. The role of PPARγ in embryonic development of Xenopus tropicalis under triphenyltin-induced teratogenicity. Sci Total Environ. 2018;633:1245-1252.
- Zhang Z, Jia Y, Almeida P, Mank JE, van Tuinen M, Wang Q, Jiang Z, Chen Y, Zhan K, Hou S, Zhou Z, Li H, Yang F, He Y, Ning Z, Yang N, Qu L. Whole-genome resequencing reveals signatures of selection and timing of duck domestication. Gigascience. 2018;7(4).
- Brutman JN, Zhou X, Zhang YZ, Michal JJ, Stark B, Jiang Z, Davis JF. Mapping diet-induced alternative polyadenylation of hypothalamic transcripts in the obese rat. Physiol Behav. 2018;188:173-180.